2021 NCAA Tournament bracket: Opening lines, odds, spreads for Sweet 16 games in March Madness

The first weekend of the 2021 NCAA men’s basketball tournament was definitely madness. Though three No. 1 teams (Baylor, Gonzaga and Michigan) made it through the first weekend, Illinois did not. In fact, this year’s Sweet 16 has four teams that are double-digit seeds. Two Cinderella teams, Loyola Chicago and Oregon State, will tip off on Saturday, March 27, for a slot in the Elite 8. 

The lines from William Hill Sportsbook indicate some potentially close games are on the horizon. Only two spreads — No. 1 Gonzaga and No. 5 Creighton in the West Regional, and No. 3 Arkansas vs. No. 15 Oral Roberts in the South — are double digits. Everything else is at 6.5 points or less. A Pac-12 showdown between No. 6 USC and No. 7 Oregon in the West is separated by a single point. 

Will the Pac-12 continue its surprising run of dominance through the tourney? Will the remaining No. 1 seeds keep advancing or will more madness prevail? Here are your Sweet 16 lines heading into the second weekend of action: 

Sweet 16

South Regional

No. 1 Baylor (-6.5) vs. No. 5 Villanova
No. 3 Arkansas (-11) vs. No. 15 Oral Roberts

Midwest Regional

No. 8 Loyola Chicago (-6.5) vs. No. 12 Oregon State
No. 2 Houston (-6) vs. No. 11 Syracuse

East Regional

No. 1 Michigan (-3) vs. No. 4 Florida State
No. 2 Alabama (-5.5) vs. No. 11 UCLA

West Regional

No. 1 Gonzaga (-13.5) vs. No. 5 Creighton
No. 6 USC (-1) vs. No. 7 Oregon

Published: 2021-03-23 15:11:04

Tags: #NCAA #Tournament #bracket #Opening #lines #odds #spreads #Sweet #games #March #Madness

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